The lost chord: microchimerism and allograft survival

Microchimerism and Renal Transplantation: Doubt Still Persists

Background: The Presence of donor leukocytes in recipients of organ allograft has been shown even several years after transplantation. However, it remains unclear whether this donor cell microchimerism plays an effective role in allograft acceptance or is simply a consequence of immunosuppressive conditions in recipients. Objective: To study microchimerism in a group of kidney transplant recipi...

The liver allograft, chronic (ductopenic) rejection, and microchimerism: what can they teach us?

T HICKENING of the most internal layer of the arterial walls in a human allograft (arterial intimal fihromu~­ dll;lr hyperplasia) was first reported in 1955 hy the pathol-1I!!I't Gustav Dammin. in collaboration with Hume. I Since I';cn. many different terms have heen used to describe this l'llmplication of allogeneic kidney transplantation: obliter-a\l\'c arteriopathy (OA). transplant atheroscl...

Routes to allograft survival.

Association of CCR5-59029 A/G and CCR2-V64I Variants with Renal Allograft Survival

Background: Despite advances in the medical care of renal transplant recipients which have led to an improvement in allograft survival, renal allograft rejection is still a major ob-stacle to successful organ transplantation. Understanding the mechanisms contributing to allograft rejection will be of great importance for the development of efficient antirejection strategies. Objective: The aim ...

Arterial hypertension and renal allograft survival.

CONTEXT Several observational studies have investigated the significance of hypertension in renal allograft failure; however, these studies have been complicated by the lack of adjustment for baseline renal function, leaving the role of elevated blood pressure in allograft failure unclear. OBJECTIVE To examine the relationship between blood pressure adjusted for renal function and survival af...